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Given certain caveats, the information obtained through single-cell research has introduced the possibility of improving CAR-T therapies against cancers by manipulating the expression of key metabolism-related genes, proteins or metabolites, leading to CAR-T cell products better suited for immunotherapy

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Therefore, this data set is unique, to our knowledge, and allowed a comprehensive analysis of rhythmic genes, protein expression, and associated metabolic pathways, as well as the effect of the deletion of the circadian clock regulator BMAL1 on these processes (of note, BMAL1 is a transcription factor that may have functions unrelated to the circadian clock)

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