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Other downstream effectors of FOXO1 may also contribute to the regulation of sarcopenia through alternative mechanisms, which requires a more comprehensive phenotypic analysis in future studies

For the B 12 bolus experiment, mice were administered 5 g vitamin B 12 (Sigma, V2876) dissolved in water by oral gavage on day 6 after the start of doxycycline treatment, and blood samples were taken by submandibular collection just before and 24 h after the bolus

Human Correlation: Findings from a 2023 human study found that a higher serum MOTS-c concentration correlated with "greater muscle mass, force, and power generated during jumping" in healthy subjects

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