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Molecular mechanism of redox signaling A variety of chemical and physical agents are capable of serving as the signaling molecules in response to oxidative stress, the most well-known of which are H 2 O 2 , NO, Ca 2+ , and cytokines

This open groove binding pocket is shown to be hydrophobic (white) and surrounded by positively charged residues (blue)

doi: 10.1016/j.arres.2021.100015 240 SariolA.PerlmanS

MDA formation is the result of decomposition of the unstable peroxides derived from polyunsaturated fatty acids TBARS may not be an effective marker for GSH