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In this case one would expect a build up in inactive CN-Cbl due to the cyanide produced during smoking

We believe transitioning the manufacturer from the severe supply chain disruption reduction or the likely to be in shortage reduction to the shortage reduction, by beginning the shortage reduction clock as set forth in 428.301(b)(2)(i)(A) or (b)(2)(ii)(A) after the severe supply chain disruption reduction or likely to be in shortage reduction no longer applies, and gradually declining the rebate reduction over time could help prevent exacerbation of the shortage