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Bankir, L., Bouby, N., Trinh-Trang-Tan, M.-M., Ahloulay, M

However, research into ferroptosis mechanisms in CHD remains in its early stages, with significant questions regarding its relationship with other cell death pathways and the clinical efficacy of ferroptosis-targeting interventions requiring further investigation

Alkylation, reduction and labeling are usually performed on cell lysates and though protein extraction is performed using acidic or sometimes anaerobic conditions, it does not entirely preclude that modifications of the cysteine redox state occur during the procedure or that the modifications are insufficiently trapped

Moreover, many types of RGC tolerate loss of transported survival-promoting factors, whereas the lack of sustained RGC survival in retinas supplemented with neurotrophic factors argues against the obligatory consequences of their loss in animals with blocked axonal transport