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Due to high levels of a UV-A chromophore in the lens (122) that mimics that of the human UV filter, a similar pattern of lens GSH distribution with lower levels of GSH in the nucleus relative to the cortex (183), and a similar age-dependent pattern of nuclear disulfide formation (184), it is proposed that guinea pigs are the best non-primate model currently available for the study of UV-A exposure and cataract ( However, while there are many benefits to the use of guinea pigs as a model of human UV exposure, it is also important to consider inconsistencies between humans and guinea pigs

Quercetin chelates metals and disrupts the STAT1/PPAR balance, promoting M2 polarization [528]

doi: 10.1111/j.1365-3040.2011.02400.x 53 OgawaK.Hatano-IwasakiA.YanagidaM.IwabuchiM