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[7] Drugs or toxins that have a pharmacological (type A) hepatotoxicity are those that have predictable dose-response curves (higher concentrations cause more liver damage) and well characterized mechanisms of toxicity, such as directly damaging liver tissue or blocking a metabolic process

Kreymerman A, Weinstein JE, Vadgama N, Shah SH, Nahmou MM, Belle KC, Ji MH, Xia X, Faust A, Van Der Merwe Y, Buickians DN, Cho IJ, Huynh SK, Verma S, Russano K, Jin XL, Karakikes I, Steketee MB, Goldberg JL

CRISPR-Cas9-mediated genome editing increases lifespan and improves motor deficits in a Huntingtons disease mouse model