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In this work, we explored the biological effect of nano-SARs, by developing a microenvironment-responsive in vivo self-assembled peptide-ferriporphyrin conjugates ( Gi-F-CAA ) for improving tumor penetration, accumulation and binding affinity with GPX4, ultimately synergistically enhancing ferroptosis-based anticancer activity

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Results - Subcutaneous implantation of Ehrlich tumor cells into the right thigh of the hind limb of mice resulted in significant decrease in tissue catalase and tissue glutathione reductase with significant increase in tissue MDA, tissue cholesterol and tissue TNF- compared to the control untreated group (Table 2, Figure 1)

Computational design of MmpL3 inhibitors for tuberculosis therapy