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This proportional muscle loss is consistent with weight loss from any cause, including dietary restriction or bariatric surgery, but the rapidity of weight loss with these medications may make this effect more clinically apparent

The therapeutic potential of resveratrol: a review of clinical trials

In addition, high levels of ROS can initiate the inflammatory process by activating several inflammatory transcription factors such as nuclear factor kappa B (NF-B), activator protein 1 (AP-1), and signal transducer and activator of transcription 3 (STAT3), as well as cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor- (TNF-) [6]

however, the biological origin of aging-associated chronic inflammation is largely unknown