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This may also be a consequence of underlying assumptions of medium homogeneity underlying conventional attenuation-based analysis, even after accounting for overlying tissue, and high sensitivity of attenuation-based outcomes to shadowing 30, 67

Biomedicines 10:945 Saxena M, Burke A, Pavlick A, Blazquez A, Gimenez G, Meseck M, Donovan M, Rodriguez D, Castillo-Martin M et al (2022) Abstract CT108: immunogenicity of poly-ICLC matured dendritic cells as an adjuvant for NY-ESO-1 and Melan-A-MART-1 peptide vaccination compared to Montanide ISA-51 VG, in study subjects with melanoma in complete clinical remission but at high risk of disease recurrence

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