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Periodontitis (pair-e-o-don-TI-tis), or periodontal disease, is an infection of the gums that destroys the soft tissue in the mouth and eventually leads to erosion of the bone that surrounds your teeth

A considerable percentage of the worlds population has at least one variant of this gene

Together, these limitations reveal a fundamental weakness in the translational pipeline: Preclinical models, often biologically reductionist and poorly representative of human pathology, remain inadequate to support the development of interventions with reproducible and clinically relevant neuroprotective effects

Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery