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Figure 6 Figure 6C provides a detailed heatmap visualization of the identified metabolites, showing a marked increase in the levels of phospholipids (PGP, PI, PCs, LysoPCs, and LysoPEs) in the vehicle group

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The consequences of Nrf2 impairment in CF include weakened intrinsic antioxidant defense capacity and increased intracellular H 2 O 2 levels, which contribute to the overproduction of pro-inflammatory cytokines like IL-6 and IL-8, directly linking defective antioxidant response to CFs characteristic chronic inflammation (Chen et al., 2008)