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Although physical examination and laboratory evaluation of most men with ED may not reveal the exact diagnosis, clinical and biochemical evaluation presents an opportunity to identify comorbid conditions [328]

Aside from the traditional protein-based biomarkers, there is an increased interest on the development of analysis methods for newer metabolite-based biomarkers, including TMAO [3]

A meta-analysis focused on complex reproductive histories confirms that for women over 35 with DOR, PCOS, or those undergoing ART cycles, meta-analyses can show meaningful marker improvements, but evidence certainty remains low and effects vary by subgroup and duration

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