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This imbalance can be caused by intense exercise, UV exposure, pollution, or poor diet

GH SECRETION IN RELATION TO ADIPOSITY AND GONADAL STEROIDS Obesity is associated with decreased GH secretion and responsiveness to secretagogues

Moreover, ECM stiffness is sensitive to exogenous TGF- stimulation through inhibiting the interaction of inner nuclear membrane protein LEM domain-containing protein 3 (LEMD3) and SMAD2/3

10.1016/j.heliyon.2019.e02645 [DOI] [PMC free article] [PubMed] [Google Scholar] Farhadnejad H., Asghari G., Mirmiran P., Mirmiran P., Yuzbashian E., Azizi F