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These effects of raloxifene and NAC on TGF1 signaling and endoglin expression are particularly promising to favor cancer therapy

doi: 10.1080/15548627.2015.1009778 147 CortesJRugoHSCesconDWImS-AYusofMMGallardoCet al

In HD, a compromised function of astrocytes can elicit a variety of cellular mechanisms, including transcriptional dysregulation, impairment of mitochondrial function, synaptic dysfunction, endoplasmic reticulum (ER) stress, and reduced levels of trophic factors, which cause pathological injury to the medium spiny neurons (Caron et al., 2018