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These could include symptoms such as itching, a rash/hives, swelling especially around the face or throat, or difficulty breathing

It turns out that even in mice that lack these receptors, fat loss takes place when AOD9604 is administered Though the beta-3-adrenergic receptor likely plays a role in fat loss secondary to AOD9604, at least one other mechanism must be in play as well

Maybe the gastrointestinal side effects were intolerable, maybe they have a personal or family history that makes the GLP-1 class a poor fit

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