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Description

A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT

In addition, we found Hcy-induced neurodegeneration-like pathology changes of mitochondria via inhibiting the NAD + /Sirt1 pathway, including defects in mitochondrial morphology, mitochondrial biogenesis, and mitophagy, ultimately leading to impairments of synapse and cognition