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Additionally, new PDE4 inhibitors have been developed to modify the inflammatory process and have demonstrated satisfactory clinical outcomes, highlighting the implication of novel therapeutic interventions in treating inflammatory-related disorders

These insults lead to the release of damage-associated molecular patterns (DAMPs), including high mobility group box 1, heat shock proteins, S100 proteins, and ATP, which activate innate immune components such as Kupffer cells, neutrophils, natural killer cells, natural killer T cells, and mast cells

No significant differences were found between these two subgroups, suggesting that this therapy regimen is not associated with death or persistence of Mtb detection in cultures after 60 days of treatment ( Table S3 )

Differences in nucleotide hydrolysis contribute to the differences between erythrocyte 6-thioguanine nucleotide concentrations determined by two widely used methods