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This universal solubility results in ALA being commonly referred to as the Universal Antioxidant and allows it to be particularly effective in providing its antioxidant benefits to the cells of our nervous system and brain where its molecular structure permits it to cross the blood-brain barrier

10.1093/ije/dyv316 28

In a cross-over design, patients switched between placebo and EGCG treatment after 6 months, allowing further assessment of EGCG's effects

This indicates the need for further optimization of the pharmacokinetics of different administrative routes and treatment paradigm for improved long-lasting effects