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Abstract Significance: The antiulcer peptide, stable gastric pentadecapeptide BPC 157 (previously employed in ulcerative colitis and multiple sclerosis trials, no reported toxicity (LD1 not achieved)), is reviewed, focusing on the particular skin wound therapy, incisional/excisional wound, deep burns, diabetic ulcers, and alkali burns, which may be generalized to the other tissues healing

Standard dosing protocols range from 1 to 2 mg daily via subcutaneous injection, with 8 to 12 week cycles followed by 4 to 6 week rest periods

Research suggests the peptide works through hormetic mechanisms where lower doses may trigger stronger adaptive healing responses in certain tissue types

If GI side effects are manageable, add cagrilintide at 0.25 mg weekly starting in week 5, while simultaneously increasing retatrutide to 2 mg as per its standard titration