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In studies investigating the regulation of oxidative stress in mast cells by H 2 (Itoh et al., 2009), it was found that H reduces the levels of NADPH oxidase subunits (such as p40 phox, p47 phox, and p67 phox) in the cell membrane while increasing their levels in the cytoplasm, selectively interfering with the membrane localization of these subunits

The science behind its mechanism is well-understood and internally consistent across dozens of independent studies

Acetylcholine-induced vasodilatation in the human hypertensive kidney: inhibition by muscarinic receptor antagonism