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During ischemia, there is a lack of blood flow due to hypoxia and an accumulation of toxic metabolites

After four weeks, the diameter of micro vessels at the fingertips and thus microcirculation was significantly increased in 53.8% of the patients supplemented with Pycnogenol compared to 32% of subjects of the placebo group ( supplemented subjects compared to placebo-controlled people in the study

The possible explanation could be due to the differences in bioavailability of green tea, as bioavailability and transformation of EGCG, the predominant catechin in green tea, differs significantly between humans, mice and rats 44

Detection assays for LR3 have been published in peer-reviewed analytical literature (Mongongu et al