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The decided inclusion criteria was: published case reports and series describing IGS patients, studies reporting patients of any age, sex or ethnicity with either genetically confirmed diagnosis or clinical diagnosis with documentation of vitamin B12 malabsorption and proteinuria, studies reporting explicit details on the dosage, frequency and route of administration of B12

It is potentially appropriate for some, in the right context, with realistic expectations, on top of an addressed foundation, with a defined cycle and a defined endpoint

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Subsequent analyses were performed using residual plasma samples from 19 of these 20 subjects