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While DAMPs signal cellular stress or damage through receptors such as TLR4, cGASSTING, and NLRs, PAMPs mimic microbial infection and trigger proinflammatory responses via PRRs, particularly TLRs 165 and C-type lectin receptors (CLRs)

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The argument: the hype and the evidence are telling two different stories Heres what the mouse data actually shows, and it is worth reading carefully because it is genuinely the whole case