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TNF- can activate brain microglia, prompting their transition from a resting to an activated state, leading to the release of inflammatory mediators and ROS, exacerbating neuroinflammation, accelerating the degeneration of the substantia nigra region, and ultimately damaging dopaminergic neurons to drive PD progression [33, 443]

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Symptoms of psycho-logical distress andsuicidal ideation among banana workers witha history of poisoning by organophos-phateor n-methyl carbamate pesticides

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