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Some side effects typically appear right after a dose increase and fade as the body adapts

Recurrent loss of NFE2L2 Exon 2 is a mechanism for Nrf2 pathway activation in human cancers

For best results on hyperpigmentation, it should be combined with good skincare (brightening creams, exfoliants, sun protection) and possibly other dermatologic treatments, depending on the severity of the issue

These findings highlight the therapeutic potential of preserving mtCK function and ensuring adequate creatine availability as part of strategies aimed at stabilizing mitochondrial performance and preventing bioenergetic failure