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Clinical studies concerning the effect of drugs modulating the insulin sensitivity (such as the peroxisome proliferator-activated receptor (PPAR)- agonists) are ongoing in order to provide new potential treatment to improve both the inflammatory status and the CV outcome in RA patients (Table 2)

However, some reports indicate that protein and proteome abundance tends to be higher in the evening and night, whereas others find the highest protein levels during daytime hours (1.371.43 g/100 mL at 12 PM and 6 PM)