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A recent phase II clinical trial in Parkinsons disease, which assessed DFP in 372 newly diagnosed, untreated PD patients over 36 weeks, revealed that DFP not only failed to improve disease symptoms but was associated with a worsening of motor and non-motor symptoms compared to placebo (Devos et al., 2022)

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After controlling for many factors that are known to influence risk of cancer, the researchers reported a 30% increase in lung cancer risk associated with the use of vitamin B12 (taken as an individual vitamin) and a 40% increase in risk for those who took B6

Oral administration of l-carnitine (3 g/d) with omega-3 fatty acids could increase carnitine palmitoyl-transferase-I activity and relieve clinical symptoms of CFS 642