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Under stressful conditions, the concomitant release of WRKY40-JMJ17 and WRKY40-HY5 can boost the expression of ABI5 by increasing both the chromatin accessibility and activity of transcription factor (Wang et al., 2021b)

Notably, AG-211 induced cell differentiation in leukemia cells from IDH2-mutant expressing mice and it synergized with Flt3 inhibition to reduce leukemic cell burden in vivo