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Novak et al., 2000

Comparison of hormonal profile before and after NAC treatment Mean values of FSH (4.14 mU/ml 0.17 vs

doi: 10.1111/brv.12759 35 ChenL.YangJ.-Y.WangD

7.3 Overarching challenges and future directions Future research priorities include clarifying the context-dependent duality of IGF-1, delineating its protective versus pathogenic roles across disease stages and cell types, and mapping crosstalk with core PAH pathways such as BMPR2/TGF- signaling