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Moreover, in TNF--stimulated ECs, the copper-dependent ATOX1-TRAF4 interaction promotes nuclear translocation and initiates ROS-dependent inflammatory responses, solidifying this axis as a promising therapeutic target [45]

For the image analysis and western blotting results, significant differences between different groups were tested with two-tailed ANOVA if no between-subject effect was considered, followed by a two-tailed Tukey multiple comparison test

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Two cases of acatalasemia in Hungary