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Gaby (2002) is an uncontrolled case series describing approximately 800-1,000 patients treated over 11 years clinical observation, not a controlled trial

One of the most common questions people have when starting doxycycline is which medicines to avoid entirely, not just space out

reported a case of mixed-type AN responding favorably to calcipotriol.[28] Miscellaneous treatment Other beneficial therapies (case reports) include fish oil.[11,27] 20% podophyllin in alcohol[29] (for benign AN) topical colecalciferol[30] and surgical excision.[27] Urea, salicylic acid and triple-combination depigmenting cream (tretinoin 0.05%, hydroquinone 4%, fluocinolone acetonide 0.01%) with sunscreens are other options.[24] ORAL TREATMENT Oral retinoids Oral retinoids (isotretinoin, acitretin) can be effective;[30] improvement requires large doses and extended courses, and relapses are described

Immune-deficient NOD-SCID-IL2RG-/- mice (NSI mice, GIBH) were used as recipients for in vivo transplantation experiments