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Metformin has been found to produce a more significant degree of weight loss in patients with polycystic ovary syndrome (PCOS), a complex endocrine disorder with symptoms including diabetes, obesity, infertility and heart disease (Li et al, 2021)

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The bone marrow cells were collected by centrifuging at 350 g for 5 min after the lysis of red blood cells

One thing to consider is that because ME/CFS is a severely disabling disease, many patients are house or bedbound and are unable to visit the clinics multiple times for follow-up analyses (39), even though these very severe cases are estimated to be around 25% of the ME/CFS cases (39, 587)