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Surgery becomes a reasonable option when non-surgical treatments havent provided sufficient improvement after 6-12 months, when curvature is severe enough to prevent intercourse, or when the emotional impact is significantly affecting your quality of life

In anterograde regulation, proteins encoded by the nuclear genome are transferred to the mitochondria to perform functions ( 2+ release ( Mitochondrial biogenesis is mainly controlled by a network of transcription factors in the nucleus, including peroxisome proliferator-activated receptor (PPAR), peroxisome proliferator-activated receptor (PPAR), estrogen-related receptors (ERRs), cylic AMP (cAMP) response element-binding protein (CREB), forkhead box (FOXO), and peroxisome proliferator-activated receptor coactivator-1 (PGC-1) ( Testosterone promotes biogenesis by activating the AR/PGC-1/TFAM pathway in the skeletal muscle ( Pgc-1 and Tfam genes in C 2 C 12 myogenic cells ( Pgc-1 and Nrf-1 are directly regulated by AR

Yuan et al., 2016), but also enhance the sensitivity of cancer cells to chemotherapy drugs or metabolic signaling inhibitors (Xie et al., 2016

10.1126/science.aaw5473 49 FengY.PathriaG.Heynen-GenelS.JacksonM.JamesB.YinJ.et al (2021)