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doi: 10.1007/s40620-020-00789-y 21 FitzGeraldG

In cases of extreme DNA damage, for example due to ischemic injury, PARP1 hyperactivation leads to NAD + and ATP depletion, resulting in cell death by necrosis or apoptosis [104,105,106]

There were 23 clinical studies published between 2020 and 2025 that support collagen as a nutraceutical treatment that showed improvement in various skin attributes, but investigations are lacking on collagens effectiveness on scalp, hair, and nail health, which warrants further examination