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However, since CHX only partially reduces its protective effect, this mechanism is not strictly required, indicating the existence of additional, protein synthesis-independent pathways

However, science is particularly interested in it because of its many physiological, endocrine and modulatory effects, such as its ability to alter corticotropin levels, inhibit somatostatin secretion, normalize blood pressure, reduce stress, influence sleep rhythms, or chronic pain perception

MTHFR mutations affect the ability of the body to convert folate into its usable form

5 Department of Pediatrics and Committee on Genetics, The University of Chicago, Chicago, Illinois, USA