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Even a recent 2026 review concludes the same thing that GHK-Cu appears safe but the evidence is largely preclinical and comprehensive human RCTs are lacking (Wojcieszuk et al., 2026)

AD is a complex multifactorial pathology, including multiple cycles and subcycles of self-amplifying neurodegenerative process [5],[6]

doi: 10.1186/1471-2350-11-167

Activation of Tissue Remodeling Proteases GHK-Cu activates matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in a balanced way that facilitates controlled extracellular matrix remodeling breaking down damaged collagen and replacing it with new, organized fibrillar collagen rather than scar tissue