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Symptoms That Indicate a Clinical Evaluation Is Warranted Persistent knee pain that interferes with walking, stairs, or daily activities Morning stiffness lasting more than 1530 minutes Swelling that recurs or persists Grinding, clicking, or crepitus during knee movement Difficulty rising from a chair or getting in and out of a car Pain not adequately controlled by over-the-counter medications Progressive loss of function or range of motion These symptoms can result from osteoarthritis, post-traumatic changes, meniscal pathology, or inflammatory arthritis conditions that require imaging and physical examination to differentiate

Using the Nernst equation (or equivalently, from the Boltzmann distribution), a ten-fold change in the product/reactant ratio corresponds to an increase of 6 kJ/mol in free energy (2 k B T)

Diabetes, 35: 668-674

Sensation varies by location and size