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The FDA also recommends examining hard clinical endpoints such hepatic decompensations, transplant free survival, and all-cause mortality, although these results are not necessarily needed prior to drug approval given the long length of follow up potentially required

As compared to patients younger than 65 years of age, the mean elimination half-life in the elderly was prolonged (7 hours after an IM dose) (2)

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Although many people develop psoriasis first, some people experience joint pain, morning stiffness, or swollen fingers months before any visible skin symptoms appear