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That enzyme is now known to be a member of a class of enzymes found in almost all cells (Vignais 2002)

Oxidative stress also induces the stabilization of HIF-1, enhancing angiogenesis and metastasis [101]

Evidence from these findings demonstrates that the disruption of these processes leads to the lungs inability to maintain homeostasis and recover from injury, resulting in a reduction in mucociliary clearance