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npEDCs have a low lipid solubility resulting in a relatively short half-life in humans and animals whereas POPs are highly lipophilic chemicals that are not readily biodegradable (Cho et al., 2020)

In colorectal cancer, ~65% of lymphatic and distant metastases arose from independent subclones in the primary tumors, whereas ~35% of cases shared a common subclone origin (153, 155)

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