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The peptide activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in a dose-dependent manner, leading to nuclear translocation and activation of transcription factors including c-Fos, c-Jun, and early growth response-1 (Egr-1) that drive expression of genes involved in cell growth, migration, and angiogenesis

For the first time, a pharmacological obesity treatment, semaglutide (at a weekly dose of 2.4 mg), has been shown to reduce major adverse cardiovascular events in people with obesity and established cardiovascular disease

View on PubMed Malinda KM, Sidhu GS, Mani H, et al

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