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Twenty subjects were randomized to receive the active cream and serum system (TPX) (Replenix Pure Hydration hyaluronic acid serum and Replenix Neckletage cream, Topix in West Babylon, New York), while 11 subjects were randomized to receive the vehicles alone in serum and cream format

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Of those, 4.6 million are associated with colder than optimum temperatures, and 0.5 million are associated with hotter than optimum temperatures