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5.8 miR-153-3p To assess the influence of miR-153-3p on neuronal apoptosis, an experiment was performed in SH-SY5Y cells utilizing a mimic of miR-153-3p and a negative control

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After correction using the ComBat method ( Supplementary Figures 1C, D ), dataset differences among samples significantly decreased, and the clustering structure of RA and normal control groups in principal component space became clearer, indicating that the data processing workflow effectively enhanced data quality and the reliability of subsequent analyses