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The fact that numerous mutations of the LYR motif have been shown in experimental systems to prevent binding of the chaperone HSC20 (Maio et al

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Among the causes suggested for CFS include damage to parts of the brain governing cognition, memory, mood, energy and perception, an altered stress response, an unbalanced immune system, a hidden chronic infection, excessive production of free radicals, reduced intracellular glutathione, abnormal sympathetic nervous system activity, cardiac dysfunction and others

In such circumstances, the additives, rather than the collagen, are generating the oil imbalance