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Some trials experimented with doses up to 50 mg per day

Signs and Symptoms of Vitamin B12 Deficiency Early symptoms: Weakness and fatigue Pale skin Headaches Mild mood changes Intermediate symptoms: Tingling or numbness in hands and feet Breathlessness Heart palpitations Mouth ulcers or a red, swollen tongue (early to intermediate signs) Advanced symptoms: Memory problems Depression, anxiety, mood swings Poor balance or coordination Weight loss, poor appetite Constipation or loose motions Visual disturbances In some cases, long-term deficiency can cause permanent nerve damage , so early detection is key

Taking a balanced view of your financial life As we develop and maintain your plan, we consider both sides of your balance sheet both your assets and your liabilities

[4] Sun X, Deng Y, Fu X, Wang S, Duan R, Zhang Y