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Lung Myofibroblasts Promote Macrophage Profibrotic Activity through Lactate-induced Histone Lactylation

Another mechanism by which pepsin can perpetuate its harmful effects is by reducing carbonic anhydrase-III levels, which play a fundamental role in local protection against the deleterious effects of stomach acid content (Reference Gill, Johnston and Buda34)

Vitamin C also regenerates other antioxidants such as vitamin E and glutathione, enhancing the body's overall antioxidant network

Resource and Training Requirements Implementing improved diagnostic approaches requires substantial training investments that many healthcare systems are reluctant to make