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TNFR-1 exerts a negative influence on hippocampal adult neurogenesis,656667 whereas TNFR-2 is involved in promoting neurogenesis.6869 TNF- is also closely associated with synaptic plasticity by inducing -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors that mediate glutamatergic activity.70 Because human neural stem cells have both TNFR-1 and TNFR-2, whether neurogenesis is enhanced or inhibited depends on the microenvironment in the CNS and the context of insults

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At the molecular level, AHK-Cu also increases VEGF (vascular endothelial growth factor) production to improve scalp blood flow, and upregulates SOD (superoxide dismutase) to reduce the oxidative stress that triggers DHT-driven follicle miniaturization one of the primary mechanisms behind androgenetic alopecia