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Cases of resolution and progression suggest a dynamic and reversible pathology potentially amenable to timely treatment

Oral amycretin showed 13.1% weight loss at 12 weeks, offering the possibility of an oral dual GLP-1/amylin agonist

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In the present study, we tested the hypothesis that NRF2 activation via dietary supplementation with Protandim would prevent salt-induced oxidative stress and endothelial dysfunction and down-regulation of the expression of two key vascular antioxidant enzymes [Cu/Zn SOD (SOD1) and Mn SOD (SOD2)] in two established animal models of pressure-independent vascular dysfunction induced by high salt diet (Sprague-Dawley rats and Syrian hamsters)