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Description

The expression of ced-3/ICE rapidly induces apoptosis, demonstrating that this gene encodes a cysteine protease essential for programmed cell death [127129]

Otherwise, MM cells with overexpression of PLR-3 have higher aerobic glycolytic rate, OXPHOS and ATP production by promoting glucose uptake and lactate excretion, enhancing the levels of proteins regulating glycolysis and enzymes in the serine/glycine synthesis pathway [165]